rs200314808
This is a variant in the ATL1 gene that changes a glutamate to an lysine.
▶ClinVar annotation
Hereditary spastic paraplegia 3A (SPG3A)
View on ClinVar →About ATL1
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
View all ATL1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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