rs2008514

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

intelligence

Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele A
OR 10.24
p 1.0e-24
N 269,867
Meta-analysisLarge GWAS
European

physical activity measurement, body mass index

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele A
OR 0.03
p 2.0e-17
N 161,368
Meta-analysisLarge GWAS
multi-ancestry

body mass index

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele A
OR 0.03
p 1.0e-8
N 123,097
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Common variants in BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1 show association with obesity‐related variables in Spanish Roma population
AssociationN=3,210Alaitz Poveda et al.(2014)· American Journal of Human Biology

This study performed fine mapping of the obesity-associated region chr16p11.2 by screening the coding regions of APOBR, SULT1A1, SULT1A2, and TUFM genes in 95 extremely obese children and adolescents. Two APOBR variants, rs180743 (p.Pro428Ala) and rs3833080 (p.Gly369_Asp370del9), showed significant association with obesity (p=0.002 and p=0.003 respectively) in case-control analysis of 1,873 obese cases versus 435 lean controls, with odds ratios of 1.27 and 1.25 per allele.

Traits studied:Body mass indexExtreme obesityObesity
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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