rs201390621
This is a protein-altering variant in the SIGLEC14 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sialic acid-binding Ig-like lectin 14 amount
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.46
p 8.0e-41
N 10,708
Large GWAS
European
Allele A
OR 0.45
p 3.0e-13
N 3,301
Large GWAS
European
protein measurement
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.32
p 3.0e-20
N 10,708
Large GWAS
European
About SIGLEC14
Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in ficolin-1-rich granule membrane and tertiary granule membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SIGLEC14 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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