rs2021163

This is a downstream gene variant variant in the PPP1R11 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of MHC class I polypeptide-related sequence A in blood, level of MHC class I polypeptide-related sequence B in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.13

p 6.0e-42

N 47,745

Large GWAS

European

About PPP1R11

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

View all PPP1R11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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