rs2041733
This variant is located in the CLEC16A gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
atopic eczema
Budu-Aggrey A et al. “European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.” Nature Communications 14(1):6172 (2023)
Allele C
OR 0.94
p 4.0e-95
N 864,982
Meta-analysisLarge GWAS
European
Pasanen A et al. “Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset.” The Journal of Investigative Dermatology 144(11):2417-2425 (2024)
Allele C
OR 0.08
p 1.0e-22
N 1,094,060
Large GWAS
multi-ancestry
Paternoster L et al. “Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature Genetics 47(12):1449-1456 (2015)
Allele C
OR 1.08
p 3.0e-11
N 116,863
Large GWAS
multi-ancestry
Ellinghaus D et al. “High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.” Nature Genetics 45(7):808-12 (2013)
Allele C
OR 1.23
p 3.0e-15
N 7,874
Large GWAS
European
Eczematoid dermatitis
Grosche S et al. “Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.” Nature Communications 12(1):6618 (2021)
Allele C
OR 0.90
p 8.0e-22
N 400,449
Large GWAS
European
allergic disease
Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele T
OR 0.03
p 2.0e-13
N 477,968
Large GWAS
European
allergic disease, age at onset
Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele T
OR 0.03
p 2.0e-13
N 117,130
Large GWAS
European
About CLEC16A
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
View all CLEC16A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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