rs2043090

This variant is located in the LRMDA gene.

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Research that mentions this SNP (1)

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Genetic variants associated with disordered eating
AssociationN=2,564Tracey D. Wade et al.(2013)· International Journal of Eating Disorders

This GWAS examined genetic variants associated with disordered eating in 2,564 female twins using four eating disorder phenotypes (anorexia nervosa spectrum, bulimia nervosa spectrum, purging via substances, and disordered eating behaviors). Six regions reached suggestive significance (p<5×10⁻⁷), implicating CLEC5A, LOC136242, TSHZ1, and SYTL5 for anorexia nervosa spectrum; NT5C1B for bulimia nervosa spectrum; and ATP8A2 for disordered eating behaviors. No variants reached genome-wide significance at p<10⁻⁸.

Traits studied:Anorexia nervosa spectrumBulimia nervosa spectrumDisordered eating behaviorsEating disordersPurging via substances
PubMedDOIMetascience Observatory

About LRMDA

This gene encodes a leucine-rich repeat protein. The encoded protein is thought to play a role in melanocyte differentiation. Mutations in this gene have been associated with autosomal recessive oculocutaneous albinism 7 (OCA7). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

View all LRMDA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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