rs204999

This is a intergenic variant variant.

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

membranous glomerulonephritis

Stanescu HC et al. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. The New England Journal of Medicine 364(7):616-26 (2011)
Allele G
OR 2.44
p 9.0e-40
N 2,894
Large GWAS
European

total blood protein measurement

Franceschini N et al. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. American Journal of Human Genetics 91(4):744-53 (2012)
Allele A
OR 0.03
p 3.0e-9
N 35,707
Meta-analysisLarge GWAS
multi-ancestry

Research that mentions this SNP (1)

Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case–control samples
ReviewMartin Tesli et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This review comprehensively summarizes the latest genetic studies on schizophrenia, including family studies (heritability ~80%), genome-wide association studies, epigenetic mechanisms, candidate gene investigations, and next-generation sequencing findings. Key GWAS findings identified 108 schizophrenia-associated loci including variants in MIR137 (rs1625579), TCF4 (rs12966547), CSMD1 (rs10503253), CACNA1C (rs4765905), ANK3 (rs10761482), and MHC region variants, with evidence for polygenetic inheritance involving both common SNPs and rare copy number variations.

Traits studied:Auditory steady-state responseAutism spectrum disorderBipolar disorderCognitive impairmentMental retardationSchizophreniaSchizophrenia endophenotypesSchizophrenia with general psychopathologic symptomsSchizophrenia with negative symptomsSchizophrenia with positive symptomsSensory processing disorderTreatment-resistant schizophreniaUnipolar depression

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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