rs20576

This is a variant in the TNFRSF10A gene that changes a glutamate to an alanine.

▶

ClinVar annotation

Benign★★★☆
2 submitters1 publication
View on ClinVar →
▶

Research that mentions this SNP (2)

▶
Evaluation of trail receptor 1 (DR4) polymorphisms C626G and A683C as risk factors of hepatocellular carcinoma
AssociationN=160Naglaa F. Alsalawy et al.(2018)· Journal of Medical Virology

This case-control study of 160 Egyptian patients with HCV-related liver disease evaluated two TRAIL receptor 1 (DR4) polymorphisms as risk factors for hepatocellular carcinoma (HCC). The C626G variant (rs20575) showed a significant association with HCC risk (OR=2.01 for C allele carriers, p=0.003), while A683C (rs20576) alone did not. The combined haplotype of C allele at rs20575 and A allele at rs20576 showed substantially increased HCC risk (OR=2.85, p>0.001).

Traits studied:HCCHepatocellular carcinoma
PubMedDOIMetascience Observatory
▶
The Glu228Ala polymorphism in the ligand binding domain of death receptor 4 is associated with increased risk for prostate cancer metastases
AssociationN=702Tanja Langsenlehner et al.(2008)· The Prostate

A prospective study of 702 prostate cancer patients found that carriers of the TNFRSF10A 228Ala allele (rs20576) had significantly increased risk of metastases after radiation therapy, with a relative risk of 2.47 (95% CI 1.10-5.54; P = 0.028) in a multivariate Cox regression model adjusting for age and risk group. The polymorphism lies in the ligand-binding domain of death receptor 4 and may impair TRAIL-induced apoptosis, suggesting a novel independent prognostic marker for prostate cancer metastasis.

Traits studied:Prostate cancer metastases
PubMedDOIMetascience Observatory

About TNFRSF10A

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

View all TNFRSF10A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…