rs2072115

This association study examined the relationship between three intronic SNPs in the RAPGEF3 (Epac-1) gene and anxiety and depression phenotypes in two independent samples. In the Dutch sample (n=910), rs2072115 showed a significant dominant effect for anxiety and depression, with the G-C-C haplotype associated with lower anxiety and neuroticism scores. In the USA replication sample (n=684), rs2074533 showed a significant additive effect on a genetic factor score, with haplotypes G-C-C and A-C-T showing opposite directional effects. Both samples showed associations between Epac-1 variants and anxiety/depression but with different SNPs or opposite effect directions, likely due to differences in linkage disequilibrium between populations.