rs2072438

This is a intergenic variant variant in the PHF19 gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

rheumatoid arthritis

Lei Jiang et al. “Novel Risk Loci for Rheumatoid Arthritis in Han Chinese and Congruence With Risk Variants in Europeans” Arthritis &amp; Rheumatology (2014)
Allele T
OR 1.14
p 3.0e-9
N 1,895
Large GWAS
multi-ancestry
▶

Research that mentions this SNP (1)

▶
TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
AssociationN=2,322Tae‐Un Han et al.(2009)· Arthritis &amp; Rheumatism

A case-control association study of 1,316 Korean RA patients and 1,006 controls found that rs7021206 in TRAF1 intron 3 is significantly associated with rheumatoid arthritis susceptibility (OR 1.21, P = 0.0037), while rs3761847, which is associated with RA in Caucasians, showed no association in Koreans due to different linkage disequilibrium patterns. Fine-mapping identified a 66-kb haplotype region spanning TRAF1 containing variants associated with RA across both Asian and Caucasian populations.

Traits studied:Rheumatoid arthritis
PubMedDOIMetascience Observatory

About PHF19

Enables methylated histone binding activity. Involved in negative regulation of gene expression, epigenetic. Located in ESC/E(Z) complex. [provided by Alliance of Genome Resources, Apr 2025]

View all PHF19 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…