rs2075713
This is a regulatory region variant variant in the VSIG2 gene.
▶Research that mentions this SNP (1)
▶Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene‐based case–control study and gene expression analysisAssociationN=4,598Kazutaka Ohi et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A case-control study of 2,019 schizophrenia patients and 2,579 Japanese controls found the rs12807809-rs12278912 haplotype in the NRGN gene (chromosome 11q24.2) significantly associated with schizophrenia (global P = 0.0042). The TG haplotype was associated with increased risk (OR = 1.14, P = 0.0019), while the TA haplotype was protective (OR = 0.85, P = 0.0053). Gene expression analysis demonstrated the high-risk TG haplotype had significantly lower NRGN expression than the protective TA haplotype (P = 0.007 in HapMap samples, P = 0.002 in combined case-control samples).
About VSIG2
Predicted to be involved in lipid metabolic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all VSIG2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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