rs2082412
This is a downstream gene variant variant.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
psoriasis
cutaneous psoriasis measurement, psoriasis
▶Research that mentions this SNP (2)
▶Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritisMeta-analysisN=13,050Kun-Ju Zhu et al.(2013)· Rheumatology International
Meta-analysis of 11 studies examining IL12B polymorphisms rs3212227 and rs6887695 in psoriasis and psoriatic arthritis. For rs3212227, pooled odds ratios for the minor allele were 0.688 (95% CI 0.650-0.729) for psoriasis and 0.707 (95% CI 0.628-0.797) for PsA; for rs6887695, pooled ORs were 0.704 (95% CI 0.670-0.739) for psoriasis and 0.677 (95% CI 0.599-0.767) for PsA, demonstrating significant protective associations with both variants.
▶Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility lociMeta-analysisN=17,698Patsopoulos NA et al.(2011)· Annals of Neurology
This meta-analysis of 7 genome-wide association studies identified three novel multiple sclerosis susceptibility loci: rs170934 near EOMES (3p24.1, OR=1.17, P=1.6×10⁻⁸), rs2150702 in MLANA (9p24.1, OR=1.16, P=3.3×10⁻⁸), and rs6718520 near THADA (2p21, OR=1.17, P=3.4×10⁻⁸). The analysis encompassed 5,545 cases and 12,153 controls and identified 10 additional loci with suggestive evidence of association (P<1×10⁻⁶), including IL12B, TAGAP, PLEK, and ZMIZ1, which are shared with other inflammatory diseases.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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