rs2084202
This is a synonymous variant in the DBI gene — it does not change the protein's amino acid sequence.
▶Research that mentions this SNP (2)
▶Candidate gene association study of type 2 diabetes in a nested case‐control study of the EPIC‐Potsdam cohort – Role of fat assimilationAssociationN=576Eva Fisher et al.(2007)· Molecular Nutrition & Food Research
Candidate gene association study screening 15 genes involved in fat assimilation for type 2 diabetes susceptibility. In 192 cases and 384 controls from EPIC-Potsdam, six SNPs showed significant associations: FABP6 Thr79Met (rs1130435, OR=0.45, 95% CI 0.22-0.92) showed the strongest protective effect; DBI rs2084202 and rs8192506 (Met71Val), PTGES2 rs13283456 (Arg298His, OR=0.64), SLC27A5 promoter variant (OR=0.54), and novel CLPS Ala109Cys variant (OR=5.83) also associated with diabetes risk. Results provide preliminary evidence for fat assimilation genes in type 2 diabetes susceptibility but require further verification.
▶Association of acyl‐CoA‐binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populationsAssociationN=1,665Eva Fisher et al.(2007)· Molecular Nutrition & Food Research
This study evaluated the association of 8 SNPs in the acyl-CoA-binding protein (ACBP) gene with type 2 diabetes (T2D) in two independent German populations. In EPIC-Potsdam (192 cases, 384 controls), the rs2084202 A allele showed decreased T2D risk (OR 0.63, 95% CI 0.41-0.96). This finding was partially replicated in KORA (226 cases, 863 controls) with borderline significance (OR 0.72, 95% CI 0.51-1.01), providing evidence that ACBP rs2084202 may be associated with reduced T2D risk in Caucasian populations.
About DBI
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
View all DBI variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…