rs2109019

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

corneal resistance factor

Simcoe MJ et al. “Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases.” Human Molecular Genetics 29(18):3154-3164 (2020)

Allele A

OR 0.09

p 1.0e-22

N 106,030

Large GWAS

European

corneal hysteresis

Simcoe MJ et al. “Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases.” Human Molecular Genetics 29(18):3154-3164 (2020)

Allele A

OR 0.07

p 2.0e-18

N 106,041

Large GWAS

European

Agents acting on the renin-angiotensin system use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.04

p 4.0e-10

N 416,256

Large GWAS

multi-ancestry

pulse pressure measurement

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele A

OR 0.19

p 9.0e-10

N 526,001

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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