rs2123886

This is a intron variant variant in the TMPRSS11E gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sphingomyelin measurement

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele A

OR 0.03

p 1.0e-9

N 126,671

Large GWAS

multi-ancestry

About TMPRSS11E

Predicted to enable serine-type peptidase activity. Involved in cognition. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all TMPRSS11E variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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