rs2131755

This is a regulatory region variant variant in the CRISPLD2 gene.

▶

GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Inguinal hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)

Allele G

OR 1.09

p 2.0e-14

N 275,546

Major Consortium StudyLarge GWAS

European

diverticular disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.05

p 3.0e-13

N 560,597

Major Consortium StudyLarge GWAS

multi-ancestry

Maguire LH et al. “Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.” Nature Genetics 50(10):1359-1365 (2018)

Allele A

OR —

β 0.003

p 2.0e-10

N 409,728

Large GWAS

European

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele G

OR 6.59

p 4.0e-11

N 1,508,659

Large GWAS

multi-ancestry

About CRISPLD2

Predicted to enable glycosaminoglycan binding activity. Involved in face morphogenesis. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]