rs2132570

This nested case-control study (5,253 cases, 4,963 controls) examined 16 SNPs in IGF pathway genes and their associations with prostate cancer risk, testing gene-environment interactions with dietary protein intake. Although the 16 SNPs were significantly associated with circulating IGF-1 or IGFBP-3 levels as expected, none were significantly associated with prostate cancer risk, and the SNP-protein interactions did not substantially differ by protein intake after multiple testing correction.

This case-control study examined genetic variants in IGF-I, IGFBP-1, and IGFBP-3 genes in relation to proliferative benign breast disease (BBD) in 359 cases and 359 controls from the Nurses' Health Study II. Higher circulating IGFBP-3 levels were significantly associated with increased BBD risk (OR 1.70, p-trend = 0.03), while minor alleles of IGFBP-3 SNPs rs3110697 and rs2132570 were associated with significantly lower BBD risk (OR 0.6 and 0.2, p-trend = 0.02). Three other IGFBP-3 SNPs (rs2854744, rs2960436, rs2854746) were strongly associated with circulating IGFBP-3 levels.

This study investigated the association between common genetic variation in IGF1, IGFBP1, and IGFBP3 genes and mammographic density in 819 women from the Multiethnic Cohort. Only weak evidence was found for associations: rs35767 (IGF1, p=0.03) was associated with 3.2% lower mammographic density, rs35539615 (IGFBP1, p=0.05) with higher density, and rs2453839 (IGFBP3, p=0.01) with lower density. Ethnicity significantly modified the associations for IGFBP3 variants.