rs2159759
This variant is located in the TMEM178B gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
smoking initiation
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele G
OR 0.01
p 4.0e-11
N 2,669,029
Large GWAS
European
About TMEM178B
Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all TMEM178B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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