rs2171363

This variant is located in the TPH2 gene.

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Research that mentions this SNP (1)

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HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers
Meta-analysisN=32,750Alessandro Serretti et al.(2007)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This dissertation investigated the genetic basis of violent criminal behavior, antisocial personality disorder (ASPD), and broader antisocial behavior through GWAS and meta-analyses in Finnish and international populations. Study I identified an intronic CDH13 variant (rs11649622, OR=2.7, p=4.19×10⁻⁶) associated with extremely violent offending, replicated in homicide offenders (p=5.3×10⁻⁷, OR=2.17). Study II revealed the first genome-wide significant association between LINC00951 variant rs4714329 (OR=1.59, p=1.6×10⁻⁹) and ASPD. Study III meta-analysis of 16,400 individuals found no genome-wide significant associations with broader antisocial behavior, though polygenic risk scores explained ~5% of phenotypic variance.

Traits studied:AggressionAlcohol use disorderAntisocial behaviorAntisocial personality disorder (ASPD)Conduct disorderDelinquencyExtremely violent offendingHomicide/murderImpulsivityRule-breaking behaviorViolent criminal behavior
PubMedDOIMetascience Observatory

About TPH2

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]

View all TPH2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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