rs2182168

This variant is located in the PYROXD2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

arginine measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele G

OR 0.14

p 1.0e-17

N 8,237

Large GWAS

European

X-22162 measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)

Allele G

OR 0.06

p 3.0e-13

N 4,911

Large GWAS

European

About PYROXD2

Predicted to enable oxidoreductase activity. Involved in mitochondrion organization. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

View all PYROXD2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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