rs2186370
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
electrocardiography
Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)
Allele A
OR 0.05
p 5.0e-15
N 63,706
Major Consortium StudyLarge GWAS
European, NR
heart failure
Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele A
OR 0.03
p 3.0e-12
N 2,358,556
Large GWAS
multi-ancestry
dilated cardiomyopathy
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele G
OR 1.12
p 4.0e-11
N 402,844
Large GWAS
Jurgens SJ et al. “Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.” Nature Genetics 56(12):2636-2645 (2024)
Allele G
OR —
β 0.098
p 1.0e-8
N 955,733
Large GWAS
multi-ancestry
hypertrophic cardiomyopathy
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele A
OR 1.21
p 2.0e-15
N 8,361
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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