rs2189246
This variant is located in the PCLO gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
irritable bowel syndrome
Alemany S et al. “Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.” Journal of Translational Medicine 21(1):272 (2023)
Allele A
OR 0.01
p 2.0e-10
N 887,490
Large GWAS
European
About PCLO
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
View all PCLO variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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