rs2190242
This is a intron variant variant in the CRHR2 gene.
▶Research that mentions this SNP (1)
▶CORTICOTROPIN RELEASING HORMONE RECEPTOR 2 (CRHR-2) GENE IS ASSOCIATED WITH DECREASED RISK AND SEVERITY OF POSTTRAUMATIC STRESS DISORDER IN WOMENAssociationN=491Erika J. Wolf et al.(2013)· Depression and Anxiety
This candidate gene association study of 491 trauma-exposed veterans and partners identified two SNPs in CRHR-2 (rs8192496, rs2190242) associated with reduced PTSD risk and severity, with effects specific to women. The minor alleles of both SNPs were significantly associated with lower PTSD diagnosis and symptom severity after multiple testing correction.
About CRHR2
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
View all CRHR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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