rs2228615
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hypertension, COVID-19
▶Research that mentions this SNP (2)
▶Genetic variants conferring susceptibility to gastroschisis: a phenomenon restricted to the interaction with the environment?Meta-analysisN=434Victor M. Salinas-Torres et al.(2018)· Pediatric Surgery International
This systematic review analyzed genetic associations with gastroschisis from 1980-2017, identifying 14 SNPs from 10 genes associated with crude risk and 30 SNPs from 14 genes with stratified risk. Four SNPs showed significant associations: rs4961 (ADD1, p=0.023), rs5443 (GNB3, p=0.002), rs1042713 (ADRB2, p=0.007), and rs1042714 (ADRB2, p=0.006). The findings suggest genetic susceptibility in gastroschisis is not restricted to gene-environment interactions, with blood pressure regulation genes playing a significant role in vascular disruption pathogenesis.
▶ICAM gene cluster SNPs and prostate cancer risk in African AmericansAssociationN=677Hankui Chen et al.(2006)· Human Genetics
A case-control study in African American men (286 cases, 391 controls) confirmed that ICAM1 SNPs -9A/C (rs5490, OR=2.5) and K469E (rs5498, OR=1.8) are associated with prostate cancer risk in familial disease. A common ICAM haplotype containing the -9A/C variant was significantly associated with prostate cancer (P=0.03), particularly in men with family history. Unlike previous findings in European populations, ICAM5 SNPs were not associated with prostate cancer in African Americans.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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