rs2233945

This is a downstream gene variant variant in the PSORS1C1 gene.

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Research that mentions this SNP (1)

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HCP5 genetic variant (RS3099844) contributes to Nevirapine-induced Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis susceptibility in a population from Mozambique
AssociationN=103Paola Borgiani et al.(2014)· European Journal of Clinical Pharmacology

This case-control study examines the association between HCP5 and PSORS1C1 genetic variants and nevirapine-induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) in 27 patients and 76 controls from Mozambique. The HCP5 rs3099844 variant allele was significantly associated with SJS/TEN susceptibility (OR=2.03, P=0.039), and the TA haplotype carrying both variant alleles showed higher risk (OR=3.44, P=0.003), with evidence of gene-gene interaction between HCP5 and PSORS1C1.

Traits studied:Nevirapine-induced Stevens-Johnson Syndrome (SJS)Toxic Epidermal Necrolysis (TEN)
PubMedDOIMetascience Observatory

About PSORS1C1

This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region. [provided by RefSeq, Sep 2011]

View all PSORS1C1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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