rs2240727
This variant is located in the TOMM7 gene.
▶Research that mentions this SNP (1)
▶Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signalsMeta-analysisN=2,583Below JE et al.(2011)· Diabetologia
Genome-wide association study (GWAS) of type 2 diabetes in 837 Mexican-Americans cases and 436 controls from Starr County, Texas, combined with meta-analysis of 967 cases and 343 controls from Mexico City. The study identified 49 high-quality SNPs in 14 genomic regions associated with type 2 diabetes, including novel loci in PER3, PARD3B, EPHA4, TOMM7, PTPRD, and IL34. Top signals showed odds ratios ranging from 1.26 to 1.83. Functional annotation revealed significant enrichment of expression quantitative trait loci (eQTL) in muscle and adipose tissues among top associated variants.
About TOMM7
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]
View all TOMM7 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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