rs2267717

This is a intron variant variant in the CRHR2 gene.

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Research that mentions this SNP (2)

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CORTICOTROPIN RELEASING HORMONE RECEPTOR 2 (CRHR-2) GENE IS ASSOCIATED WITH DECREASED RISK AND SEVERITY OF POSTTRAUMATIC STRESS DISORDER IN WOMEN
AssociationN=491Erika J. Wolf et al.(2013)· Depression and Anxiety

This candidate gene association study of 491 trauma-exposed veterans and partners identified two SNPs in CRHR-2 (rs8192496, rs2190242) associated with reduced PTSD risk and severity, with effects specific to women. The minor alleles of both SNPs were significantly associated with lower PTSD diagnosis and symptom severity after multiple testing correction.

Traits studied:PTSD symptom severityposttraumatic stress disorder
PubMedDOIMetascience Observatory
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An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population
AssociationN=964Xing Gu et al.(2010)· Human Genetics

A case-control study in Chinese Han population examining rs2267716 polymorphism in the CRHR2 gene found significant association with HBV-related hepatocellular carcinoma. The C allele was associated with increased HCC susceptibility compared to healthy controls (OR = 1.55, 95% CI 1.13-2.15, P = 0.007) and non-HCC HBV patients (OR = 1.61, 95% CI 1.13-2.31, P = 0.009).

Traits studied:Hepatitis B virus infectionHepatocellular carcinoma (HBV-related)
PubMedDOIMetascience Observatory

About CRHR2

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

View all CRHR2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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