rs2272382
This variant is located in the TUB gene.
▶Research that mentions this SNP (1)
▶TUB is a candidate gene for late-onset obesity in womenAssociationN=2,694Snieder H. et al.(2008)· Diabetologia
This replication study confirms that TUB SNP rs2272382 is associated with increased obesity measures in postmenopausal women from a large UK twin cohort (N=2,694). In postmenopausal women homozygous for the minor allele, rs2272382 showed associations with BMI (beta=0.92 kg/m², p=0.036), waist circumference (beta=2.73 cm, p=0.013), and percent central fat (beta=2.43%, p=0.027), with significant interaction with menopausal status (p=0.036). The association was confirmed by sibling transmission disequilibrium test in discordant dizygotic twins.
About TUB
This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
View all TUB variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…