rs2274273

This is a downstream gene variant variant in the DLGAP5 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

protein measurement

de Boer RA et al. “A genome-wide association study of circulating galectin-3.” Plos One 7(10):e47385 (2012)
Allele A
OR 0.18
p 2.0e-188
N 3,776
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic Variants in the Vicinity of LGALS‐3 Gene and LGALS‐3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study
AssociationN=785Ana Djordjevic et al.(2016)· Journal of Clinical Laboratory Analysis

This case-control study of 785 Serbian subjects (485 advanced carotid atherosclerosis patients, 300 controls) examined two genetic variants in the LGALS-3 gene (rs2274273 and rs17128183) for association with carotid atherosclerosis risk and LGALS-3 mRNA expression. No statistically significant associations were found between either variant and advanced carotid atherosclerosis or plaque phenotypes (all p > 0.0125 after Bonferroni correction). However, rare allele carriers of both variants showed significantly higher LGALS-3 mRNA expression in carotid plaque tissue (p = 0.039), suggesting these variants may affect gene expression despite lacking association with disease risk.

Traits studied:advanced carotid atherosclerosiscarotid plaque phenotypes
PubMedDOIMetascience Observatory

About DLGAP5

Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in cytosol; nucleus; and spindle. [provided by Alliance of Genome Resources, Jul 2025]

View all DLGAP5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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