rs227584
This is a protein-altering variant in the HROB gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
femoral neck bone mineral density
Estrada K et al. “Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.” Nature Genetics 44(5):491-501 (2012)
Allele A
OR —
β 0.060
p 3.0e-24
N 32,961
Meta-analysisLarge GWAS
multi-ancestry
About HROB
Predicted to enable single-stranded DNA binding activity. Involved in DNA synthesis involved in DNA repair and interstrand cross-link repair. Located in site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]
View all HROB variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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