rs2278415
This is a protein-altering variant in the ZNF350 gene.
▶Research that mentions this SNP (1)
▶Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese womenAssociationN=1,192Xiang Huo et al.(2009)· Journal of Cancer Research and Clinical Oncology
Case-control study of 568 Chinese breast cancer cases and 624 controls investigating polymorphisms in BRCA1, BRIP1, and ZNF350. Individual SNP associations were modest and non-significant, but joint analysis revealed significant gene-gene interaction: ZNF350 rs4986773 variant homozygotes combined with BRCA1 rs799917 variant homozygotes conferred increased breast cancer risk (OR = 2.03, 95%CI = 1.02-4.05, p-int = 0.059), suggesting BRCA1 and ZNF350 jointly contribute to breast cancer susceptibility.
About ZNF350
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]
View all ZNF350 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…