rs2278557

This is a downstream gene variant variant in the PPP4C gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Diuretic use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele G

OR 0.06

p 4.0e-13

N 229,086

Major Consortium StudyLarge GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.05

p 4.0e-13

N 407,812

Large GWAS

multi-ancestry

About PPP4C

Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in several cellular components, including chromatin; cytosol; and nucleoplasm. Part of protein phosphatase 4 complex. [provided by Alliance of Genome Resources, Jul 2025]

View all PPP4C variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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