rs2279829

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GWAS Catalog Trait Associations (16)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele T

OR 35.73

p 1.0e-279

N 33,748

Large GWAS

European

Sha Z et al. “The genetic architecture of structural left-right asymmetry of the human brain.” Nature Human Behaviour 5(9):1226-1239 (2021)

Allele T

OR —

p 1.0e-9

N 32,256

Large GWAS

European

cerebral cortex area attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele T

OR 28.93

p 5.0e-184

N 33,748

Large GWAS

European

Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)

Allele T

OR —

p 1.0e-17

N 35,657

Large GWAS

European

Grasby KL et al. “The genetic architecture of the human cerebral cortex.” Science (new York, N.y.) 367(6484) (2020)

Allele T

OR 16.28

p 2.0e-49

N 33,992

Large GWAS

European

cortical thickness

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele T

OR 22.13

p 2.0e-108

N 33,748

Large GWAS

European

Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)

Allele T

OR —

p 1.0e-17

N 35,657

Large GWAS

European

brain connectivity attribute

Sha Z et al. “Genetic architecture of the white matter connectome of the human brain.” Science Advances 9(7):eadd2870 (2023)

Allele C

OR 10.85

p 2.0e-27

N 30,810

Large GWAS

European

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)

Allele C

OR 0.12

p 6.0e-24

N 21,081

Major Consortium StudyLarge GWAS

European

brain physiology trait, language measurement

Mekki Y et al. “The genetic architecture of language functional connectivity.” Neuroimage 249:118795 (2022)

Allele C

OR 9.37

p 8.0e-21

N 32,186

Large GWAS

European

social inhibition quality, attention deficit hyperactivity disorder, substance abuse

Karlsson Linnér R et al. “Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.” Nature Neuroscience 24(10):1367-1376 (2021)

Allele C

OR 0.01

p 3.0e-18

N 2,776,348

Large GWAS

European

alcohol consumption quality

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele T

OR 0.01

p 4.0e-18

N 2,428,851

Large GWAS

European

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)

Allele T

OR 0.01

p 1.0e-8

N 1,039,210

Large GWAS

European

sexual activity behaviour attribute

Karlsson Linnér R et al. “Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.” Nature Genetics 51(2):245-257 (2019)

Allele T

OR 0.02

p 1.0e-13

N 370,711

Large GWAS

European

smoking status measurement

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)

Allele T

OR 0.01

p 1.0e-11

N 1,359,002

Large GWAS

European

parietal lobe volume

van der Lee SJ et al. “A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.” Communications Biology 2:285 (2019)

Allele T

OR 0.95

p 4.0e-10

N 16,016

Large GWAS

multi-ancestry

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Research that mentions this SNP (1)

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“The Heidelberg Five” personality dimensions: Genome‐wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment

AssociationN=481Urs Heilbronner et al.(2021)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This study evaluated the use of polygenic scores (PGS) based on 10 top SNPs from European GWAS meta-analysis of antisocial behavior to predict liability to severe criminal behavior (homicide) in a Russian cohort of 227 offenders and 254 controls. A PGS based on rs993137 (CADM2), rs458806 (REV3L), rs11720703 (FOXP1), and rs1476535 (FOXP2) explained 1.5% of variance in liability to antisocial behavior, while the combined genetic model with social factors (traumatic brain injury, chronic disease, tobacco smoking) explained up to 21.2% of variance (p = 2 × 10⁻¹³), demonstrating that social factors have substantially greater predictive impact than genetic variants alone.

Traits studied:AggressionAntisocial behaviorCriminal behaviorExternalizing behaviorHomicideSevere criminal behavior

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs2279829

GWAS Catalog Trait Associations (16)

brain attribute

cerebral cortex area attribute

cortical thickness

brain connectivity attribute

brain physiology trait, language measurement

social inhibition quality, attention deficit hyperactivity disorder, substance abuse

alcohol consumption quality

sexual activity behaviour attribute

smoking status measurement

parietal lobe volume

Research that mentions this SNP (1)

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