rs2280090
This is a protein-altering variant in the ADAM33 gene.
▶Research that mentions this SNP (1)
▶Association between ADAM33 T1 polymorphism and susceptibility to asthma in AsiansMeta-analysisN=11,218Young Ho Lee et al.(2012)· Inflammation Research
Meta-analysis of 11 studies (4,124 asthma patients, 7,094 controls) found the ADAM33 T1 polymorphism (rs2280091) GG genotype associated with asthma susceptibility (OR = 2.257, 95% CI = 1.577-3.228, p = 8.42×10⁻⁷). The association was stronger in Asians (OR = 2.683, p = 1.31×10⁻⁷) and adults (OR = 1.895, p = 0.048). No association was found for ADAM33 T2 (rs2280090) or ST+7 (rs574174) polymorphisms.
About ADAM33
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
View all ADAM33 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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