rs2284552

This is a intron variant variant in the IL10RB gene.

▶

Research that mentions this SNP (2)

▶
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines
AssociationN=1,052Ovsyannikova IG et al.(2014)· Immunogenetics

This candidate gene association study identified six SNPs shared between measles and rubella vaccine immune responses in 764-1,052 healthy vaccinated subjects. Key findings include rs669260 (DDX58) associated with increased neutralizing antibody titers (p=0.02 for measles, p=0.0002 for rubella), rs2284552 (IL10RB) and rs2546893 (IL12B) associated with IL-6 secretion, and rs17860160/rs2834160 (IFNAR2) and rs2770150 (TLR4) associated with IFNγ secretion across both vaccine responses.

Traits studied:IFNγ secretionIL-6 secretionMeasles vaccine responseNeutralizing antibody titersRubella vaccine response
PubMedDOIMetascience Observatory
▶
Nucleotide variation in IL‐10 and IL‐12 and their receptors and cervical and vulvar cancer risk: A hybrid case–parent triad and case–control study
AssociationN=4,300Shehnaz K. Hussain et al.(2013)· International Journal of Cancer

This hybrid case-parent triad and case-control study examined associations between 76 tagSNPs in IL10 and IL12 cytokine pathway genes (IL10, IL12A, IL12B, IL10RA, IL10RB, IL12RB1, IL12RB2) and cervical/vulvar cancer risk. Key findings include: IL10RA rs9610 (OR=1.76, 95% CI 1.15–2.68) and rs4252314 (OR=2.23, 95% CI 1.26–3.96) associated with increased cervical cancer risk; IL12RB2 rs4297265 (OR=0.46) and rs2229546 (OR=0.43) associated with reduced cervical SCC risk; IL12B rs3181224 associated with reduced vulvar SCC risk (OR=0.30, 95% CI 0.12–0.74); and IL12RB1 rs11575934 (OR=1.51, 95% CI 1.12–2.05) associated with increased cervical adenocarcinoma risk.

Traits studied:Cervical adenocarcinomaCervical squamous cell carcinomaVulvar squamous cell carcinoma
PubMedDOIMetascience Observatory

About IL10RB

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

View all IL10RB variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…