rs228916
This variant is located in the TMPRSS6 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
iron biomarker measurement, serum iron amount
Benyamin B et al. “Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.” Nature Communications 5:4926 (2014)
Allele T
OR 0.09
p 3.0e-8
N 23,986
Large GWAS
European
About TMPRSS6
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
View all TMPRSS6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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