rs2290199

This variant is located in the CENPF gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

inflammatory biomarker measurement, YKL40 measurement

Zhang R et al. “Genome-wide study of immune biomarkers in cerebrospinal fluid and serum from patients with bipolar disorder and controls.” Translational Psychiatry 10(1):58 (2020)

Allele A

OR 20.13

p 6.0e-9

N 291

Small GWAS

European

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ClinVar annotation

Benign★★★☆

2 submitters1 publication

View on ClinVar →

About CENPF

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

rs2290199

GWAS Catalog Trait Associations (1)

inflammatory biomarker measurement, YKL40 measurement

ClinVar annotation

About CENPF

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