rs2294015
This is a protein-altering variant in the ANXA13 gene.
▶Research that mentions this SNP (1)
▶Genome‐wide association study of theta band event‐related oscillations identifies serotonin receptor geneHTR7influencing risk of alcohol dependenceAssociationN=2,159Mark Zlojutro et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This genome-wide association study identified four genes influencing theta band event-related oscillations, a heritable neuroelectrical trait associated with alcohol dependence. The strongest association for alcohol dependence risk was rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 × 10⁻⁴), with a recessive effect (OR = 1.32–1.37, P = 0.031–0.042). Other significant markers included rs4907240 in ARID5A (P = 3.68 × 10⁻⁶), rs13831 in GNAS1, and non-synonymous rs2294015 in ANXA13.
About ANXA13
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
View all ANXA13 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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