rs2298805
This is a variant in the FCER1A gene that changes a serine to an asparagine.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patientsAssociationN=368Aiyuan Guo et al.(2015)· Archives of Dermatological Research
This case-control study of 191 Chinese chronic spontaneous urticaria (CSU) patients and 177 healthy controls examined association of FCER1A SNPs (rs2298805, rs10908703, rs2494262) with disease susceptibility and response to H1-antihistamines. The rs2298805 G allele was associated with higher serum IgE levels (P = 0.011) and the rs2298805 A allele showed reduced frequency in patients unresponsive to antihistamines (OR = 8.328, P = 0.015).
About FCER1A
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
View all FCER1A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…