rs2302489
This is a 5 prime utr variant variant in the KLRD1 gene.
▶Research that mentions this SNP (1)
▶Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese populationAssociationN=500Juan Ma et al.(2010)· Journal of Medical Virology
This case-control association study of 500 Han Chinese patients analyzed genetic polymorphisms in NK cell receptor genes for association with chronic hepatitis B susceptibility. The TT genotype of rs2617160 in the NKG2D gene was independently associated with increased risk of chronic hepatitis B (P=0.044, OR=1.49, 95% CI=1.01-2.19), appearing more frequently in chronically infected patients (37.9%) than those who spontaneously cleared HBV (29.3%). Haplotype analysis of four NK receptor genes (KLRD1, KLRK1, KLRC4, KLRC1) showed no significant associations.
About KLRD1
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
View all KLRD1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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