rs2302612

This is a protein-altering variant in the IL1RL2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

interleukin 1 receptor-like 1 measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele C
OR 0.36
p 2.0e-29
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

serum ST2 amount

Ho JE et al. “Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.” The Journal of Clinical Investigation 123(10):4208-18 (2013)
Allele C
OR 0.08
p 2.0e-11
N 2,797
Large GWAS

About IL1RL2

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

View all IL1RL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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