rs2304200

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

macrophage scavenger receptor types I and II level

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.58
p 2.0e-127
N 10,708
Large GWAS
European

protein measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.26
p 1.0e-27
N 10,708
Large GWAS
European
Western D et al. “Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.” Nature Genetics 56(12):2672-2684 (2024)
Allele A
OR 0.28
p 3.0e-12
N 3,506
Large GWAS
European

blood protein amount

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele A
OR 0.26
p 4.0e-18
N 5,361
Large GWAS
European
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Research that mentions this SNP (1)

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Peptidoglycan recognition protein genes and risk of Parkinson's disease
AssociationN=990Goldman SM et al.(2014)· Movement Disorders

Case-control genetic association study of 990 participants (480 cases, 510 controls) from two independent cohorts testing 30 SNPs across four PGLYRP genes (encoding peptidoglycan recognition proteins) for association with Parkinson's disease risk. Variants in PGLYRP2 (rs3813135, rs733731, rs892145), PGLYRP3 (rs2987763), and PGLYRP4 (rs10888557, rs12063091, rs3006440, rs3006448, rs3006458, rs3014864) were significantly associated with PD risk. The strongest association was PGLYRP4 rs10888557 (5'UTR), where the CC genotype showed OR 0.15 (95% CI 0.04-0.6) compared to GG reference (P-trend = 0.0004). Most minor alleles were associated with reduced PD risk, consistent with a role for gut microbiota and immune response in disease pathogenesis.

Traits studied:Parkinson's disease
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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