rs2332175

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele A
OR 0.01
p 1.0e-14
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian

digit length ratio

Warrington NM et al. “Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero.” Human Molecular Genetics 27(11):2025-2038 (2018)
Allele A
OR 0.32
p 2.0e-17
N 12,586
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio
AssociationN=979Lawrance-Owen AJ et al.(2013)· Human Genetics

A genome-wide association study of 979 healthy adults identified SMOC1 as a novel locus strongly associated with digit ratio (2D:4D), a biomarker of prenatal sex hormone exposure. The strongest association was at rs4902759 (P = 1.41 × 10⁻⁸), with each additional C allele decreasing 2D:4D by 0.0076. Meta-analysis with an independent study yielded P = 1.5 × 10⁻¹¹. The authors propose that SMOC1, a gene critical for limb development that is regulated by sex hormones, mediates the relationship between prenatal hormone exposure and digit ratio.

Traits studied:Digit ratio (2D:4D)Prenatal testosterone exposure
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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