rs2358994
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
autoimmune thyroid disease, type 1 diabetes mellitus
Tomer Y et al. “Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes.” Journal of Autoimmunity 60:32-9 (2015)
Allele A
OR 1.87
p 2.0e-11
N 1,073
Large GWAS
European
▶Research that mentions this SNP (1)
▶Genetic risk factors for rheumatoid arthritis differ in caucasian and Korean populationsAssociationN=2,131Hye‐Soon Lee et al.(2009)· Arthritis & Rheumatism
Genetic risk factors for rheumatoid arthritis differ in caucasian and Korean populations
AssociationN=2,131Hye‐Soon Lee et al.(2009)· Arthritis & Rheumatism
A case-control study of 1,123 Korean rheumatoid arthritis patients and 1,008 controls found that genetic variants at PTPN22, TRAF1/C5, 6q23, 4q27, CD40, and CCL21 previously associated with Caucasian RA were not associated with Korean RA. The PADI4 variant rs2240340 showed strong association (p=1.15×10⁻⁸, OR=1.43), demonstrating substantial genetic heterogeneity between ethnic populations.
Traits studied:Rheumatoid arthritis
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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