rs2359142
This variant is located in the AREL1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
retinal vasculature measurement
Zekavat SM et al. “Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature.” Circulation 145(2):134-150 (2022)
Allele T
OR 0.04
p 3.0e-9
N 38,932
Large GWAS
European
About AREL1
Enables ubiquitin protein ligase activity. Involved in negative regulation of apoptotic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all AREL1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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