rs2365389

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele C

OR 0.02

p 1.0e-35

N 1,122,049

Large GWAS

European

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele C

OR 0.02

p 6.0e-25

N 694,649

Large GWAS

European

Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)

Allele C

OR —

β 0.020

p 3.0e-15

N 334,487

Large GWAS

multi-ancestry

Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)

Allele C

OR —

β 0.020

p 4.0e-13

N 309,889

Large GWAS

European

Locke AE et al. “Genetic studies of body mass index yield new insights for obesity biology.” Nature 518(7538):197-206 (2015)

Allele C

OR 0.02

p 2.0e-10

N 238,944

Large GWAS

multi-ancestry

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)

Allele C

OR 0.02

p 9.0e-14

N 158,284

Large GWAS

multi-ancestry

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)

Allele C

OR 0.04

p 3.0e-10

N 153,041

Meta-analysisLarge GWAS

multi-ancestry

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele C

OR 0.03

p 5.0e-12

N 123,097

Meta-analysisLarge GWAS

multi-ancestry

Wood AR et al. “Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.” Diabetologia 59(6):1214-21 (2016)

Allele C

OR 0.03

p 4.0e-12

N 119,688

Large GWAS

European

physical activity measurement, body mass index

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele C

OR 0.03

p 2.0e-14

N 161,368

Meta-analysisLarge GWAS

multi-ancestry

smoking behavior, body mass index

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)

Allele T

OR 0.03

p 2.0e-10

N 196,760

Meta-analysisLarge GWAS

multi-ancestry

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Research that mentions this SNP (1)

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Influence of genetic variants associated with body mass index on eating behavior in childhood

AssociationN=3,179Claire Monnereau et al.(2017)· Obesity

In a population-based cohort of 3,179 children, the study tested two weighted genetic risk scores based on 15 childhood and 97 adult BMI-associated SNPs, plus ten individual appetite/satiety SNPs, for association with eating behavior measures. The 97 SNP adult BMI risk score was nominally associated with lower satiety responsiveness (β: -0.007 SD, 95% CI -0.013, 0.000), while individual SNPs rs11030104 (BDNF) and rs10733682 (LMX1B) showed nominal associations with reduced satiety responsiveness (β: -0.057 to -0.087 SD). Overall, findings do not strongly support that BMI-associated SNPs influence eating behavior at this young age.

Traits studied:Body mass index (BMI)Enjoyment of foodFood fussinessFood responsivenessSatiety responsivenessSlowness in eating

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs2365389

GWAS Catalog Trait Associations (3)

body mass index

physical activity measurement, body mass index

smoking behavior, body mass index

Research that mentions this SNP (1)

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