rs2386584

This is a downstream gene variant variant in the PRC1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multisite chronic pain

Johnston KJA et al. “Genome-wide association study of multisite chronic pain in UK Biobank.” Plos Genetics 15(6):e1008164 (2019)
Allele T
OR 0.02
p 3.0e-11
N 387,649
Major Consortium StudyLarge GWAS
European

About PRC1

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

View all PRC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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