rs240993
This variant is located in the REV3L gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
psoriasis
Strange A et al. “A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.” Nature Genetics 42(11):985-990 (2010)
Allele A
OR 1.25
p 5.0e-20
N 7,353
Large GWAS
European
Yin X et al. “Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.” Nature Communications 6:6916 (2015)
Allele A
OR 1.20
p 1.0e-8
N 13,816
Meta-analysisLarge GWAS
multi-ancestry
Baurecht H et al. “Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.” American Journal of Human Genetics 96(1):104-20 (2015)
Allele A
OR 1.28
p 1.0e-14
N 12,244
Large GWAS
European
body height
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele C
OR 0.01
p 4.0e-13
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
About REV3L
The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
View all REV3L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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