rs2410601

This is a intron variant variant in the PSD3 gene.

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Research that mentions this SNP (1)

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Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
AssociationN=5,675Sandholm N. et al.(2014)· Diabetologia

This genome-wide association study examined genetic variants associated with urinary albumin excretion rate (AER) in 1,925 type 1 diabetes patients, with replication in 3,750 additional patients. Five SNPs in the GLRA3 gene reached genome-wide significance in the discovery stage (rs10011025 p<1.5×10⁻⁹, β=0.21), but replication showed opposite direction effects, suggesting population-specific rare variants. The strongest replication signal (p=0.026) was for rs2410601 between PSD3 and SH2D4A genes.

Traits studied:AlbuminuriaDiabetic nephropathyType 1 diabetesUrinary albumin excretion rate
PubMedDOIMetascience Observatory

About PSD3

Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse; postsynapse; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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