rs2412974

This is a intron variant variant in the HORMAD2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total blood protein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.02

p 2.0e-30

N 394,642

Large GWAS

European

level of thioredoxin domain-containing protein 15 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.03

p 2.0e-13

N 47,745

Large GWAS

European

free cholesterol:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)

Allele T

OR 0.03

p 3.0e-13

N 136,016

Large GWAS

multi-ancestry

About HORMAD2

Predicted to be involved in meiotic cell cycle and meiotic sister chromatid cohesion. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all HORMAD2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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